Atopic dermatitis: clinical phenotypes, persistence and comorbidity

Background. Atopic dermatitis is the most common skin disease among children. Its natural history heterogeneous with a difference in age of manifestation, localization lesions, severity, sensitization profiles, presence comorbid atopic conditions, and longitudinal trajectories progression. The study aimed to assess impact factors such as onset disease, family history, concomitant allergic pathology, duration breastfeeding on course development respiratory allergies, environmental that aggravate disease. Materials methods. Children (n = 88) were included from September 2020 April 2021 Kyiv, Ukraine. Symptoms allergy patients have been documented comorbidity. Results. Total 88 at time examination presented manifestations form rash, dry skin, scaling, itching, lichenization. severity was significantly related onset: children early phenotype had more severe (OR 16.261; 2.056–127.911). There no statistically significant association diseases 1.813; 0.415–7.916). A observed group 2.750; 1.123–6.735). high risk 5.604; 1.863–16.863). did not 0.778; 0.119–5.100) 1.417; 0.444–4.521). influenced by seasonality 76 (86.4 %): condition deteriorated winter. Contact animal associated exacerbation 4 (4.5 %) children, food ingestion — 20 (25 %), pollen trees grasses caused 5 (5.7 %). Conclusions. are developing allergies. Patients who develop symptoms under 2 years, well those an phenotype.